HSPB1 polyclonal antibody
产品名称： HSPB1 polyclonal antibody
英文名称： HSPB1 polyclonal antibody
产品编号： PAB18476
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of HSPB1.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S15 of human HSPB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody is specific to HSPB1.
- Form:
- Liquid
- Purification:
- Affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:20000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis.
Luo C, Pan H, Mines M, Watson K, Zhang J, Fan GH.J Biol Chem. 2006 Oct 6;281(40):30081-93. Epub 2006 Aug 11.
- 2.
- Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma.
Tremolada L, Magni F, Valsecchi C, Sarto C, Mocarelli P, Perego R, Cordani N, Favini P, Galli Kienle M, Sanchez JC, Hochstrasser DF, Corthals GL.Proteomics. 2005 Feb;5(3):788-95.
- 3.
- F-actin capping (CapZ) and other contractile saphenous vein smooth muscle proteins are altered by hemodynamic stress: a proteonomic approach.
McGregor E, Kempster L, Wait R, Gosling M, Dunn MJ, Powell JT.Mol Cell Proteomics. 2004 Feb;3(2):115-24. Epub 2003 Nov 11.
- 4.
- Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA.Mol Biol Cell. 2003 Aug;14(8):3216-29. Epub 2003 Apr 17.
- 5.
- Hsp27 upregulation and phosphorylation is required for injured sensory and motor neuron survival.
Benn SC, Perrelet D, Kato AC, Scholz J, Decosterd I, Mannion RJ, Bakowska JC, Woolf CJ.Neuron. 2002 Sep 26;36(1):45-56.
- 6.
- Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.
Hattan D, Nesti E, Cachero TG, Morielli AD.J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.
- 7.
- A strategy for the rapid identification of phosphorylation sites in the phosphoproteome.
MacDonald JA, Mackey AJ, Pearson WR, Haystead TA.Mol Cell Proteomics. 2002 Apr;1(4):314-22.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of extracts from HeLa cells using HSPB1 polyclonal antibody (Cat # PAB18476).
Peptide "+" means "peptide blocking".
- Entrez GeneID:
- 3315
- Protein Accession#:
- P04792
- Gene Name:
- HSPB1
- Gene Alias:
- CMT2F,DKFZp586P1322,HMN2B,HS.76067,HSP27,HSP28,Hsp25,SRP27
- Gene Description:
- heat shock 27kDa protein 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq
- Other Designations:
- OTTHUMP00000024846,estrogen-regulated 24 kDa protein,heat shock 27kD protein 1,heat shock protein beta-1,stress-responsive protein 27
- Interactome
- Gene Pathway