NPR1 (N-term) Peptide
产品名称: NPR1 (N-term) Peptide
英文名称: NPR1 (N-term) Peptide
产品编号: P3113
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NPR1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NPR1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
Immunofluorescence (1:300)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- A time-resolved fluorescence assay to identify small-molecule inhibitors of HIV-1 fusion.
Dams G, Van Acker K, Gustin E, Vereycken I, Bunkens L, Holemans P, Smeulders L, Clayton R, Ohagen A, Hertogs K.J Biomol Screen. 2007 Sep;12(6):865-74. Epub 2007 Jul 20.
- 2.
- Differentiation in vivo of cardiac committed human embryonic stem cells in postmyocardial infarcted rats.
Tomescot A, Leschik J, Bellamy V, Dubois G, Messas E, Bruneval P, Desnos M, Hagege AA, Amit M, Itskovitz J, Menasche P, Puceat M.Stem Cells. 2007 Sep;25(9):2200-5. Epub 2007 May 31.
- Applications
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with NPR1 polyclonal antibody (Cat # PAB3327) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 4881
- Protein Accession#:
- NP_000897;P16066
- Gene Name:
- NPR1
- Gene Alias:
- ANPRA,ANPa,GUC2A,GUCY2A,NPRA
- Gene Description:
- natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
- Omim ID:
- 108960
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM
- Other Designations:
- OTTHUMP00000035155,atrionatriuretic peptide receptor A,guanylate cyclase A,natriuretic peptide A type receptor,natriuretic peptide receptor 1,natriuretic peptide receptor A
- Gene Pathway
- Related Disease
- Carotid Stenosis
- Chorioamnionitis
- Coronary Artery Disease
- Fetal Membranes, Premature Rupture
- Genetic Predisposition to Disease
- Glaucoma
- Glaucoma
- Heart Diseases
- Hypertension
- Hypertrophy, Left Ventricular
- Mental Disorders
- Myocardial Infarction
- Obstetric Labor, Premature
- Pre-Eclampsia
- Premature Birth
- Ventricular Dysfunction